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Diethylstilbestrol
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Diethylstilbestrol

CAS: 56-53-1

MF:C18H20O2

MW:268.35

EINECS: 200-278-5

Assay: 99% min

Character: White crystalline powder.

Diethylstilbestrol (DES) also known formerly (and inappropriately) as stilboestrol (BAN), is a synthetic, non-steroidal estrogen of the stilbestrol group that was first synthesized in 1938.It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1971, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses.


In 1971, DES was shown to cause clear cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew approval of DES as a treatment for pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed.The United States National Cancer Institute recommends women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the drug. Individuals who were exposed to DES during their mothers' pregnancies are commonly referred to as "DES daughters" and "DES sons".


Medical uses:

DES has been used in the past for the following indications:

Recurrent miscarriage in pregnancy

Hormone replacement therapy for menopausal symptoms such as hot flashes and vaginal atrophy

Hormone replacement therapy for hypoestrogenism (e.g., gonadal dysgenesis, premature ovarian failure, and after oophorectomy)

Postpartum lactation suppression to prevent or reverse breast engorgement

Gonorrheal vaginitis (discontinued following the introduction of the antibiotic penicillin)

Prostate cancer and breast cancer

Prevention of tall stature in tall adolescent girls

As an emergency postcoital contraceptive