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Product Detail
Triptorelin
Detail

Triptorelin

Triptorelin CAS: 57773-63-4

Triptorelin MF: C64H82N18O13

Triptorelin MW: 1311.45

Triptorelin assay: 99% min

Triptorelin Appearance: White or slightly yellowish powder

Triptorelin Packing:according to the customer request

Triptorelin Solubility:Soluble in water or 1% acetic acid at a concentration of 1mg/ml to give a clear, colorless solutionConforms

Triptorelin Identity by HPLCThe retention is same with the reference substanceConforms


Triptorelin (GnRH):

Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl . In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh). In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy.

Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.


How often should Triptorelin be used?

1 single 100mcg dose per cycle is typically used. If you are doing more than 1 cycle a year then you would need at least 4 months between doses. If over 1mg (1,000mcg) is administered in 1 year it is possible to get castration-like shutdown of your system.


How to reconstitute Triptorelin?

Triptorelin is typically manufactured in 100 mcg amounts and is reconstituted with sterile water.

If you have a 100mcg vial then you can add any amount of sterile water to it since you will use the entire vial at one time. If you fill a 1 ml U-100 insulin syringe up to the number 20 (20 units) then this will be a suitable amount of sterile water for the peptide to dissolve.